Revolutionary Co-Delivery Technology


Vivostat has developed the revolutionary Co-Delivery system that makes it possible to co-deliver a desired substance (drugs, stem cells, skin cells) with Vivostat® Fibrin Sealant or Vivostat PRF® (Platelet Rich Fibrin)

Vast Opportunities
The opportunities with the Vivostat® Co-delivery system are vast and the system allows the surgeon to apply a selected substance easily and effectively. Furthermore, it may be possible to reduce the total cost of a procedure by using the Vivostat® Co-Delivery system.Options for Co-Delivery include:
  • Antibiotics
  • Chemotherapeutics
  • Pain medications
 Stem cells
  • Bone marrow derived
  • Adipose tissue derived
 Skin Cells





Co-delivering drugs, stem cells, skin cells, etc.., with the Vivostat® Fibrin Sealant or Vivostat PRF® solutions offers the surgeon and the patient a number of benefits:

• Topical application
• Targeting affected/desired area
• Possible higher local dose
• Possible lower systemic impact
• Improved compliance

No Thrombin
Moreover, no thrombin is added to Vivostat® Fibrin Sealant and Vivostat PRF®(unlike most other sealants and PRP products). This is beneficial to the Co-Delivery system as thrombin activation has been shown to have a negative effect on cell survival1.

The effect of the fibrin membrane
The fibrin membrane found in both Vivostat® Fibrin Sealant and Vivostat PRF®has, furthermore, been shown to postpone the degradation process of the substance. This means that the fibrin membrane ensures a slow and sustained release of the substance offering a prolonged effect





How does it work?

Up to 5.3mL of substance may be co-delivered together with the Fibrin or PRF®solution. The substance is applied using the Vivostat® Spraypen® which enables the surgeon to apply the substance accurately and intermittently throughout the entire procedure. 


The substance is loaded into the 6mL syringe and inserted into the APL 404 Applicator Unit together with the Fibrin or PRF® solution. Using the Vivostat®foot switch the surgeon initiates application. 


The substance and the Fibrin or PRF® solution is mixed once it leaves the tip of the Spraypen® and polymerizes immediately upon application - this way the substance stayes where it is intended to act.

Co-Delivery Experience

Burns: Co-Delivery with skin cells 

Full healing with only one treatment


"Successful application of keratinocyte suspension using autologous fibrin spray”.

Treatment of a 29 year old female who had a serious burn injury to her back. By co-delivering Vivostat® Fibrin Sealant with skin cells (harvested with the ReCell system) the patient only needed one session of resurfacing and went on to have full healing on the back


Queen Elizabeth Hospital Birmingham, Lt Col Prof Steven Jeffery




Wounds: Co-Delivery with antibiotic in chronic leg ulcers

Healing within 10 weeks


"In the daily practice, the targeted antimicrobial treatment together with PRF has proven to be an important treatment option. For example, in a 49 year-old patient with a three-month history of a chronic leg ulcer refractory to treatment, infected with enterobacter cloacae and colonized with pseudomonas aeruginosa, the wound was almost completely closed after 70 days of treatment with PRF/amikacin"

The Division of Infectious Diseases and Tropical Medicine of the Medical University of Vienna (Vienna General Hospital, AKH) 



1) High thrombin concentrations in fibrin sealants induce apoptosis in human keratinocytes
Gugerell et al. · Journal of Biomedical Materials Research Part A 2012; May:100(5):1239-47
2) Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma
Lardinois et al. · J Thorac Cardiovasc Surg 2006;131:697-703